Layout Elements completly messed up, maybe related to HighDPI-Mode

Hello, Holger,  

We already have a known issue regarding RadLayoutControl in HDPI scenarios. You can track its progress, subscribe for status changes and add your comments on the following link: https://feedback.telerik.com/winforms/1372652-fix-radlayoutcontrol-the-layout-is-not-correct-on-150-dpi 

Due to the specificity and complexity of the issue, I am unable to suggest a suitable solution with RadLayoutControl. 

However, I can suggest you to consider using a TableLayoutPanel when creating a DPI-aware application. Thus, you can add as many rows/columns as you need in order to arrange the controls. Dock the controls in the respective TableLayoutPanel's cell to fill the available space. The main benefits here are:
- The controls do not have specific location and size. This way when the form is resized the controls will fit in the available space.
- You can easily set Margin between the controls instead of using anchoring.
- The application will look better when it is scaled.

I hope this information helps. If you need any further assistance please don't hesitate to contact me. 

Regards,
Dess | Tech Support Engineer, Sr.
Progress Telerik

Thanks, I already stopped using RadLayoutControl, since it seems to do all it's 'magic' only in the designer and hard-codes the final positions, it's hard to modify anything programmaticly. TableLayoutPanel should do a better job, and a row-column layout, will do better in most scenarios.